The Art of Being Data-Enabled: ��ֳ�’s Approach to Delivering Innovative Patient Solutions

eCMSadmin — Mon, 27 Sep 2021 15:30:00 +0000

Mike Branson, Statistical Science & Innovation

eCMSadmin Mon 27/09/2021 - 17:30

As ��ֳ�’s Chief Data Officer, I combine my passion for data, analytics, and medicine to create meaningful solutions and innovative treatments for patients who put their trust in ��ֳ�. We use data analysis to answer questions and inform better decisions on behalf of patients and caregivers in need.

This work uses analytics, machine learning, and AI throughout our drug discovery, development, and innovation processes. For example, we’re optimizing the way we design clinical trials, selecting patients, automating the analysis of trial data, and optimizing our logistics operations. This all has a tremendous impact on how we work and how efficiently we can deliver results. And we’re expanding this work, building a platform to maximize the value of our data for the patients we serve.

Advancing the Health Solutions Lifecycle

��ֳ�’s Data Office Strategy is built around four core principles:

We are question-led and purposeful
We determine fit for purpose data operating models in ways that are responsible and efficient
We build strategically to unleash the full potential of data
We create a strong technology foundation that connects people, systems, and data.

I want to focus on the first principle – we are question-led, which contrasts with most other pharma companies who are mostly “data-driven” – meaning they take large pools of data and try to see which learnings can be extracted.

We believe our approach better serves patients, focusing us on the answers to questions that are most important to them. Questions like, “How can we improve symptoms and how quickly?”, “What is the appropriate dose of a medicine?” or “Can we predict future patient response/relapse to treatment?”

��ֳ�’s work with Stanford on severe diseases is a great example of our question-led approach. The collaboration leverages our expertise in clinical, real-world, omics, and other data sources to advance learnings in certain important areas.

Our first project with Stanford focuses on Hidradenitis Suppurative (HS), also known as acne inversa. HS is an immunological skin disease that results in debilitating quality of life for people living with the disease. The treatment journey is often long and complex with delays, misdiagnoses, and ineffective treatment. With our Stanford collaboration, we plan to further examine phenotyping, computational discovery of pathogenic mechanisms, as well as the disease burden and societal experience for people living with severe disease like HS.

The last decade has introduced new computational methods which increase the cost-effectiveness and efficiency in the pharmaceutical industry. The digitization of patient records and clinical trials, the advent of cloud computing, the growth of wearable devices, and the medical Internet of Things (mIoT) has transformed clinical development with an explosion of data. The opportunity and challenge is to remain intensely curious and creative as industry leaders in unleashing the potential of data.

For us, that’s taking form in the development of a state-of-the-art approach to large-data analytics that combines an AI approach with a Bayesian framework. In practice, it allows us to leverage the power of large data analytics even when the sample size is relatively small. In fact, our Statistical Science & Innovation group recently filed a patent application centered around an improved machine learning method that can search through a large hypothesis space to identify the most meaningful pieces of information and then use AI to predict an outcome or provide decision guidance. This innovation has already been used to inform patient stratification, clinical trial design, and precision medicine approaches for Parkinson’s disease and epilepsy.

Looking Toward the Future

These new technologies will enable ��ֳ� to make data-enabled decisions and accelerate the development of new compounds, bringing our treatments to patients faster and more safely. Ultimately, our question-led approach drives the focus towards what’s most important - using technology to deliver differentiated solutions that serve our patients.

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Embracing Digital Business Transformation to Accelerate Tailored Solutions for Patients

eCMSadmin — Fri, 05 Mar 2021 13:00:00 +0000

Embracing Digital Business Transformation to Accelerate Tailored Solutions for Patients

Emmanuel Caeymaex, Patient Value Immunology ＆ US Solutions

eCMSadmin Fri 05/03/2021 - 14:00

��ֳ�’s ambition is to provide patients with unique outcomes, to ensure they have access to the solutions they need, and to deliver the best individual experience. In a world where digital technology is significantly changing the way patients experience their care, how healthcare professionals practice medicine, and how companies like ��ֳ� discover and develop solutions and bring them to patients, this ambition is both being challenged and encouraged. All of this has been accelerated by the pandemic.

Our approach to this digital business transformation essentially focuses on selectively applying advanced analytics and digital engagement tools, at scale, and on developing digital care solutions for multisided digital platform ecosystems to transform the patient experience. We also believe in partnering with pioneers at the forefront of technology and data-powered innovation for greater impact to help drive our healthcare system’s evolution further. Together, we are accelerating research and development cycles and digitalizing our operations to meet our customers where they are while helping patients live their best lives, whatever that means for them.

Discovery
In drug discovery, we are using computational design and artificial intelligence to more efficiently identify compounds that have a higher chance of leading to effective therapies. We’re working hard to increase the impact of a treatment through a deeper understanding of the biological causes of disease, systematically provide better research data-driven insights to enable the faster discovery of therapeutic molecules, and improve a patient’s overall journey.

As part of that work, we recently entered a new multi-year, strategic collaboration with Microsoft, to combine their Artificial Intelligence (AI) technologies and cutting-edge platforms to discover and develop new medicines in a more efficient and innovative way.

Development
In the development of new medicines, we digitalize our clinical study protocols and have provided decentralized clinical trials, which have resulted in the continuity of patient care through remote visits even during the COVID-19 pandemic. Gaining real-time access to patient feedback enrolled in our clinical trials is important to us, and we often use patient experience surveys to help us better understand the patient experience. For one of our key assets, the results were outstanding, with a NPS score of 53, far exceeding the industry benchmark of 22 specific to the indication. This tells us we are on the right track with enhancing the patient’s overall experience as they embark on this important part of their health care journey.

Go-to-Market and Digital Care Transformation
In the delivery of medicines and solutions to the market, we’ve expanded our use and mix of distinctive channels and of predictive analytics to generate a better, more tailored, experience for our customers. This has become even more important during the pandemic as we understand changing physician needs. We have been reimagining frontline ways of working in several markets, with eager adoption of new tools by our colleagues in the field. This promises to result in more fulfilling work, a leading capability, and an increasingly effective go-to-market model.

We also recently announced the launch of Nile AI, Inc., a new independent company created to improve care for people living with epilepsy, their caregivers, and healthcare providers. Nile is developing an epilepsy care management platform that serves as a digital extension of the healthcare provider and provides patients with peace of mind between consultations, with the ultimate goal of shortening the path to optimal care.

Partnering for Impact
As we continue to transform the way care is delivered, we believe that partnering can make a greater impact. Our collaboration with MyHealthTeams, an organization that creates social networks for people living with chronic conditions, has enabled us to contribute to their well-being and access to information and to gain insights into their experience of learning, treating and and coping with their disease. For instance, the MySpondylitisTeam, which focuses on spondyloarthritis, is an active patient community started in early 2018 with more than 42,000 members.

Through our work with Ali Health in China, a digital healthcare provider, we’re also exploring an innovative service model for the intelligent management of chronic diseases like epilepsy. As the first step of the strategic agreement, ��ֳ� has created an "Epilepsy Care on Alipay" account on the Alipay app to serve epilepsy patients and provide cloud-based diagnosis, treatment, and medication delivery to improve the overall patient experience.

Partnering has been central to building and scaling target digital capabilities and delivering promising results rapidly, to further support this journey of change. In many cases, we decided to pair our knowledge of a patient population with the acumen and capabilities of digital health players.

The rapid integration of digital innovation into all aspects of our business is a testament to how quickly we can adapt to the needs of patients and the ever-changing environment. Much of this stems from the size of ��ֳ� – large enough to make an impact, but small enough to remain agile. This agility provides greater opportunities for our employees to engage in work that is more creative, strategic, and transversal, and which better delivers on our goal of developing personalized experiences for people living with severe diseases.

To achieve these ambitious goals, ��ֳ� is advancing how we work and embracing our key organizational enablers of success: by unleashing the power of data; by rapidly gaining digital capabilities; and most importantly, evolving our culture and how our people approach work, by eliminating barriers to customer-centricity, being bold in our adaptability with transversal collaboration and experimentation. By empowering individuals with decision-making and an entrepreneurial mindset that flourishes within an agreed frame , we can amplify the power of scientific innovation through digital transformation, creating sustainable value, and ensuring that patients can live the lives they choose now and in the future.

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The Art of Being Data-Enabled: ��ֳ�’s Approach to Delivering Innovative Patient Solutions

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Embracing Digital Business Transformation to Accelerate Tailored Solutions for Patients

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The Art of Being Data-Enabled: ������ֳ�’s Approach to Delivering Innovative Patient Solutions

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Embracing Digital Business Transformation to Accelerate Tailored Solutions for Patients

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The Art of Being Data-Enabled: ��ֳ�’s Approach to Delivering Innovative Patient Solutions